Scientists believe cholesterol stones form when bile contains too much cholesterol, too much bilirubin, or not enough bile salts, or when the gallbladder does not empty completely or often enough. The reason these imbalances occur is not known. The cause of pigment stones is not fully understood. The stones tend to develop in people who have liver cirrhosis, biliary tract infections, or hereditary blood disorders—such as sickle cell anemia—in which the liver makes too much bilirubin.
People at risk for gallstones include
- women—especially women who are pregnant, use hormone replacement therapy, or take birth control pills
- people over age 60
- American Indians
- Mexican Americans
- overweight or obese men and women
- people who fast or lose a lot of weight quickly
- people with a family history of gallstones
- people with diabetes
- people who take cholesterol-lowering drugs
Source:
National Digestive Diseases Information Clearinghouse (NDDIC) A service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH)

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